Well Clarith's bloodline didn't carry the HER gene. Though she descended from Venomania the Netsuma line didn't carry the gene. Also after she stopped from killing Riliane and making a contract with the Demon of Wrath she went back to normal so I doubt she became afflicated with HER afterwards. 

When it comes to Kiril, the Seven Deadly Sins didn't exist until after the Levianta Disaster. 

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