Board Thread:General Discussion/@comment-6192846-20140612134000/@comment-6192846-20140812135624

It's possible imo, though we'd still need that answer on what exactly is a ghoul child (unless it's just mothy's fancy term for "just an artificially made human being").

If she was, I'd bet she'd be Ma's creation, similar in effect to homunculi or androids in other fantasy series. If she was biologically engineered, that may also explain her failed suicide attempt.