Hereditary Evil Raiser Syndrome

Hereditary Evil Raiser Syndrome, also known as simply HER, was a rare genetic condition. Resulting from Malice, those who were infected by the syndrome possessed malicious intent and a destructive personality. After extensive experimentation by Seth Twiright, the condition became a lasting presence in the Third Period.

Early History
Resulting from Malice, the syndrome spread among the gods and their kin in the Second Period and the mass outbreak of HERs led to the world's destruction. With a HER among the surviving 72 gods and kin, the HER was later sealed in Sin along with his fellow twin gods and five kin around BT 528. He later escaped and incarnated in the third world the gods created as a human: Seth Twiright.

Twiright Experiments
Starting around the BT 020s, Seth Twiright developed ghoul children to increase the number of HERs, creating clones, Pale Noël and Kiril. Once he developed another method via seeds of malice, Seth created numerous new ghoul children over the years, causing a surge in HERs rampaging throughout the Magic Kingdom. As the HERs were identified, the Leviantan government attempted to root out the evil raisers and were largely unsuccessful.

Seth later took over the second Project 'Ma' established to eliminate HERs and prevent Levianta's prophesied destruction. The scientist then implanted the ghoul child test subject, Meta Salmhofer, with the god seed, creating the human vessels for the twin gods, Hänsel and Gretel on December 27, EC 0. They later escaped from the royal institute and Seth continued experimenting in following projects. At some point, Seth began developing several objects for the purpose of becoming vessels of malice.

When the Levianta Catastrophe occurred in EC 013, virtually all HERs were wiped out in the explosion and resulting destruction caused by Levia-Behemo; at that time, the deceased HERs' seeds of malice were released into the air, causing an extremely low chance for any human to develop the syndrome. After the twin-headed dragon's body fell apart and descended into Held's Forest, its fragments fused with Hänsel and Gretel. Around the same time, Seth transferred one of the surviving ghoul children, Irina Clockworker, from her mortally injured body into a stuffed red cat before dying himself.

Vessels of Sin
In EC 014, Hänsel and Gretel murdered their foster parents, Eve and Adam Moonlit, and split Eve's Original Sin into seven fragments. Using Seth and his fellow god kin as the demons along with Eve's soul, the twins created seven vessels of sin before releasing the malice vessels into the world. Irina then began collecting them to spread malice. In December of EC 135, Irina gave the Lust sword vessel to Cherubim and allowed "Duke Sateriasis Venomania" to contract with the Demon of Lust and propagate to increase the number of HERs.

The Duke successfully impregnated Maylis Beelzenia, Mikulia Greeonio, and Lukana Octo with children that could develop Hereditary Evil Raiser Syndrome. Mikulia's bloodline was later ended with the death of her son in EC 150. Hänsel and Gretel later reincarnated as Arte and Pollo around the EC 290s, becoming the loyal servants to Duke Banica Conchita, introducing the noble to the Demon of Gluttony and killing for her. They were later devoured by Banica around August of EC 325.

On January 14, EC 457, Prim Rogzé was born as a HER. The Queen later gave birth to another reincarnation of Gretel, Ney Marlon, on November 1, EC 482. Afterward, Prim collaborated with Irina to destroy the Kingdom of Lucifenia while allowing the mage to experiment on Ney and use her as Marlon's spy and assassin. Prim was later killed by Ney in EC 505; following Ney's death soon after, Gretel's soul was absorbed into the Glass of Conchita and returned to the new demon Banica's service.

On December 27, EC 595, Hänsel reincarnated as Lemy. Later adopted by Irina posing as "Julia Abelard", the boy became her assassin for the criminal organization Père Noël. After Lemy's final death on January 30, EC 611, Hänsel's soul was absorbed into the Glass of Conchita and returned to Banica's service. Following Irina's clash with Banica and Levia, her soul was fused with Levia's and Eve Moonlit's spirits, becoming the entity of Ma. The new HER then continued collecting the vessels.

Symptoms
A Hereditary Evil Raiser, or HER, is said to be at their core an incarnation of malice, "programmed" to destroy the gods and everything they created; therefore, a HER's tendencies included physical violence, human experimentation, destruction, and deceit. As a natural prerequisite, HERs typically attempted to increase their own kind and ensure the continuation of their "mission" to spread malice by any means necessary. They likewise took immense pleasure in performing their actions.

However, HERs could be unaware of their condition and live their lives under the assumption that they were normal. Similarly, despite their predisposition toward malice, a HER could still feel guilt over their darker tendencies. As a result, HERs varied in terms of personality, with some attempting to resist their symptoms. In a similar vein, a Hereditary Evil Raiser could hide their symptoms to deceive their peers. In some cases, an individual with dissociative identity disorder could also be born with a split personality possessing HER.

Causes
Originating from Malice, all Hereditary Evil Raisers were created from the same source. A human HER could also be developed by cloning the human's body, thereby copying their entire genetic and mental makeup. A HER could also be born by implanting the zygote with seeds of malice, causing them to naturally develop the genes of malice as the fetus grew and matured; HERs could therefore be artificially engineered en masse as with ghoul children. Additionally, a human HER could be created through human forging a contract with a Demon of Sin.

Following the Levianta Catastrophe, the seeds of malice taken into the air created an environment for a human HER's natural birth. Under normal circumstances, the chance of a fetus being conceived with the HER gene was 1/65530. Similarly, the chance of a fetus with the HER gene surviving birth was 1/9999. As a result, the chance of someone being successfully born with the HER gene was 1/655234470.

Despite this extremely low probability, the offspring of one or more parents with HER exponentially increased the chances the child would inherit the gene and thereby the syndrome. As a result, family bloodlines could carry over the gene via seeds of malice throughout generations, though the chances of any given descendant developing the syndrome decreased as the family's blood thinned out over the generations.

Treatment
Originally, those who developed Hereditary Evil Syndrome had no known cure for their condition. In order to suppress the symptoms, adam and merry-go-round drugs could be administered and, in more serious cases, clockwork medicine was given. Despite this, those affected could refuse taking the medication, making it difficult to properly treat them. Later on, however, Elluka Chirclatia found a method to remove the genes of malice from HERs, effectively curing them of their condition.

Known Evil Raisers

 * Unknown Patient
 * Seth Twiright
 * Pale Noël
 * Meta Salmhofer
 * Kiril Clockworker
 * Irina Clockworker
 * Hänsel
 * Gretel
 * Arte
 * Pollo
 * Prim Marlon
 * Mariam Futapie
 * Ney Marlon
 * Lemy Abelard
 * Ma
 * Loki Freezis
 * Jorm Zusco

Curiosities

 * While pondering her use of Lemy Abelard, Irina Clockworker considered using her foster son as a means for her to become the "Master of the Hereditary Evil Raisers" or "M.O.T.H.E.R."